I've already got some stuff going with vowel mutations1 in the Proto-Indo-European language (which really needs a name at some point; calling it "the Proto-Indo-European language" is going to get old fast), all of which has to do with nouns and their plurals and declensions.
So the question is, can I also use vowel mutations for verbs? In English, that's precisely what they're usually used for, when they're still used at all: sing, sang, sung, for example. But there are still some mutations hanging around the noun system, like mouse/mice and goose/geese. And nouns that used mutations for their plurals used to be rather more common than they are today--Old English had a system a lot more like German's current one, with eight or ten different possible ways to form a plural.
Anyway, my language can be kind of unnaturally regular, since I'm planning on mutating the hell out of it for daughter langagues; this is going to be my Proto-Eastern, or perhaps even my Nostratic, though I think I'll leave aside Proto-World. But I don't know if I want the verbs to be as neat as the nouns currently are; I have not even one irregular noun. I'll have to think about it.
1: I find it bizarre that the PIEists refer to PIE as having "only one vowel" which then gets played around with by all sorts of stuff, see also "laryngeal theory". Some folks have decided that this means the reconstructions can't be accurate, since there are no known languages with only one vowel. Except it doesn't really have only one vowel; once *a and *o start making differences of meaning when they replace *e, they're phonemes, not allophones, and there are three-vowel systems all over the place.